BaleDoneen® Method Research Highlights

A Proven Strategy to Quickly Halt and Reverse Arterial Disease

The continually updated BaleDoneen® Method rapidly adapts the latest peer-reviewed science into clinical practice to keep practitioners on the leading edge of prevention. We use a team approach in which medical and dental providers work together to save lives and hearts with optimal care.

One of our recent peer-reviewed publications[1] has been hailed as “landmark” because it is the first to identify a new, treatable cause of CVD: high-risk oral bacteria from periodontal disease (PD). Also known as gum disease, PD affects the majority of adults over age 30, many of whom are unaware that they harbor a serious oral infection.

Optimal, personalized management of patients’ oral, arterial and systemic health has long been a key part of the BaleDoneen® Method. A recent peer-reviewed study conducted by Johns Hopkins[2] offers powerful scientific evidence that our unique approach to heart attack and stroke prevention can rapidly shrink arterial plaque and stabilize CVD.

Dramatic Improvements During the First Year of Treatment

The research, which included 324 of our patients, reported the following outcomes during the first year of treatment with the BaleDoneen® Method:

  • A 50% decrease in lipid-rich arterial plaque (the most dangerous kind)
  • A 43% rise in calcified plaque (the stable form that does NOT cause heart attacks and strokes)
  • A 31% drop in triglycerides
  • A 25% drop in LDL (bad) cholesterol and 6% rise in HDL cholesterol
  • A 5% decrease in systolic blood pressure

These trends continued in the second year of treatment and beyond. An earlier peer-reviewed study of our patients, published in Journal of Cardiovascular Nursing, found striking improvements in carotid intima-media thickness (cIMT) measurements, plaque burden and blood sugar over an eight-year period, as well as significant decreases in LDL cholesterol and inflammation: the dangerous duo that leads to arterial plaque buildup.


[1] Bale BF, Doneen AL and Vigerust DJ. High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. Postgrad Med J 2016;0 1-6.

[2] Cheng HG, Patel BS, Martin SS, Blaha M, Doneen AL, Bale BF and Jones SR. Effect of comprehensive cardiovascular disease risk management on longitudinal changes in carotid artery intima-media in a community-based prevention clinic. Arch Med Sci 2016 Aug 1; 12(4) 7280735.